Effects
| Name | Details | Duration | Max stacks |
|---|---|---|---|
 Shielding Echo | Bomber can activate a shield by healing or shielding the target. | 5 secs | – |
| Shielding Echo | Mines are charging. | 0.1 secs | – |
 Shishigas vulnerability | Hero's next basic attack deals additional Value unavailable magic damage to Shishiga. | 20 secs | – |
 Shrine | Cooldown Reduction is increased by Value unavailable. | 300 secs | – |
 Shrine | Health is increased by Value unavailable. | 300 secs | – |
 Shuriken Poison | Deals Value unavailable magic damage each second. | 3 secs | – |
 Sickness | All your main stats are decreased by 10%. | 180 secs | – |
 Silence | Silenced. | 5 secs | – |
| Silence | Silenced. | 5 secs | – |
| Silence | Silence. | 5 secs | – |
| Silence | Silenced. | 2 secs | – |
| Silence | Silenced. | – | – |
| Silence | Silenced. | 6 secs | – |
| Silence | Silenced. | 3 secs | – |
| Silence | Silenced. | 3 secs | – |
 Silkworm caterpillar | Health Regeneration is increased by Value unavailable | 10 secs | – |
 Singularity Blitz | Attack Speed increased by Value unavailable. | 8 secs | 4 |
 Siphoning Jinx | Enemies heal of damage dealt to you. | 10 secs | – |
 Skeletal Body | Immune to Bleed effects. | 600 secs | – |
| Skeletal Body | Immune to Bleed effects. | 600 secs | – |
| Skeleton Summoned | Drains Value unavailable mana each second. | 60 secs | – |
| Sleep | Asleep. | 5 secs | – |
 Sleep | Sleep. | 20 secs | – |
| Sleep | Sleeping. | 24 secs | – |
| Sleep | Sleeping. | 8 secs | – |
 Slow | Value unavailable is decreased by Value unavailable. | 5 secs | 20 |
 Slow | Value unavailable is decreased by Value unavailable. | – | – |
| Slow | Slowed. | 2 secs | – |
| Slow | Value unavailable is decreased by Value unavailable | 3 secs | – |
| Slow | Value unavailable is decreased by Value unavailable. | 3 secs | – |
| Slow | Value unavailable is decreased by Value unavailable. | 2 secs | – |
| Slow | Slowed by 50%. | 3 secs | – |
 Slow | Value unavailable is increased by Value unavailable | 15 secs | – |
| Slow | Value unavailable is decreased by Value unavailable. | – | – |
| Slow | Movement speed is reduced by Value unavailable. | – | – |
| Slow | Slowed by Value unavailable | – | – |
| Slow | Value unavailable is decreased by Value unavailable. | – | – |
| Slow | Value unavailable is reduced by Value unavailable. | 1 sec | 10 |
| Slow | Value unavailable is decreased by Value unavailable. | 5 secs | 1 |
| Slow | Value unavailable is decreased by Value unavailable. | 1 sec | – |
| Slow | Value unavailable is decreased by Value unavailable. | 2 secs | – |
| Slow | Target is slowed by Value unavailable. | – | – |
| Slow | Value unavailable is decreased by Value unavailable. | 3 secs | – |
| Slow | Slowed by Value unavailable. | – | – |
| Slow | Movement speed is reduced by Value unavailable. | 3 secs | – |
| Slow | Movement speed is reduced by Value unavailable. | 5 secs | – |
| Slow | Movement speed is reduced by Value unavailable. | 3 secs | – |
| Slow | Slowed Value unavailable. | 5 secs | – |
| Slow | Value unavailable is decreased by Value unavailable. | 3 secs | 1 |
| Slow | Slowed by 30%. | 3 secs | – |