 Santa's Last Stand | Skin | – | 20,000 |
 Saving Grace | Artifact | – | 135,000 |
 Savory Mushroom Soup | Dishes | – | 1,250 |
  Saw | Quest | Common | – |
 Saxaul Dander | Quest | Common | – |
 Scanned Holographic Skull | Quest | Common | – |
 Scar | Rune | – | 6,720 |
 Scarlet Neonshield | Weapon | – | 675,000 |
 Scarlet Warlance | Weapon | – | 675,000 |
 Scavenger | Weapon | – | 10,000 |
 Scavenger Shield | Weapon | – | 10,000 |
| Scavenger Shield | Weapon | – | 10,000 |
 Sci-Fi Hoverboard | Skin | – | 20,000 |
 Scolopendra Hormone | Quest | Common | – |
 Scourge Sentry | Artifact | – | 135,000 |
 Scrag bones | Quest | Common | – |
 Scrambled Targeting Chip | Quest | Common | – |
 Scream | Rune | – | 10,500 |
 Screen | Rune | – | 115,392 |
 Seaonna's Note | Quest | Common | – |
 "Secret Snack" bottles | Quest | Common | – |
| Sector 4 Alley | Skin | – | – |
 Seed packet | Quest | Common | – |
 Seer's Drone | Artifact | – | 135,000 |
 Sentient Coif | Artifact | – | 135,000 |
 Septic Seed | Quest | Common | – |
 Seraphic Protectorate | Artifact | – | 135,000 |
 Serrated | Weapon | – | 100,000 |
 Serrated Buckler | Weapon | – | 100,000 |
 Serrated Fang | Weapon | – | 100,000 |
 Shabbywood | Weapon | – | 10,000 |
 Shattered Glass | Generic | Common | 960 |
 Shelf | Quest | Common | – |
 Shell | Rune | – | 6,720 |
 Shell | Butchery | Common | 40,000 |
 Shell | Butchery | Common | 40,000 |
 Shipping Manifest | Quest | Common | – |
 Shirt | Quest | Common | – |
 Shroomageddon | Quest | Common | – |
| Shuriken | Rune | – | 125,000 |
 Shuriken | Generic | Common | 3,500 |
 Sightward | Other | – | 375 |
 Signal Transmitter Module | Quest | Common | – |
 Silica | Logging | Common | 333 |
 Silkworm Caterpillar | Herbalism | – | 102 |
 Silver 403 Mechanical Spider | Skin | – | 20,000 |
 Silver Arena Chest | Alchemy | Common | – |
 Silver Arena Chest | Alchemy | Epic | – |
 Silver Arena Chest | Alchemy | Rare | – |
 Silver Arena Chest | Alchemy | Uncommon | – |