 Door Unveiling The Hidden Truth | – | | Spawns |
| Door Zelina | – | | Spawns |
 DOPY | 39 | MobGuard | Spawns |
| DOPY-03 | – | MobGuard | Spawns |
| Dorik Oakenshield | – | NPCQuest | VendorSpawns |
| Dr. Orion Bloom | – | NPCQuest | VendorSpawns |
| Dr.Glimmiwop | – | NPCQuest | VendorSpawns |
| Drama Flower | – | | Spawns |
| Drama guitar | – | | Spawns |
| Draven Torvik | – | NPCQuest | VendorSpawns |
| Dream Glass Eye | – | | Spawns |
| Driscoll-99 | – | NPCQuest | Spawns |
 Druid Herbalist | – | NPCQuest | |
| Dungeon Guard | – | NPC | |
| Durzo "Dicey" Dunwaddle | 2 | MobGuard | Vendor |
 Dwarf Cook 02 | – | NPCQuest | |
 Dwarf Stash | – | | Spawns |
| Dwarfaton Ironcheek | – | NPCQuest | VendorSpawns |
| Dyke | – | NPCQuest | |
| Eadric Barrow | – | NPCQuest | VendorSpawns |
| Eamon Hardich | – | NPCQuest | VendorSpawns |
 Earth Deserts | – | | |
| Earth Totem | 1 | Mob | |
| East Yellow | – | | Spawns |
| East Yellow Transparent | – | | Spawns |
| Ecologist | – | NPCQuest | |
| Eddie | – | NPCQuest | VendorSpawns |
| Elara Brightfall | – | NPCVendorQuest | VendorSpawns |
| Eldric Veilstrider | – | NPCQuest | VendorSpawns |
| Eldritch Envy SIn | 19 | Mob | |
| Emigrants | – | NPCQuest | |
| Empty syringe | – | | Spawns |
| Empty1 | – | | |
 Energizer-21 | – | NPCQuest | Spawns |
| Energydrink Sildenafil | – | | Spawns |
| Engineer | – | | |
| Enriched Celestial Iron Stockpile | – | | |
| Enriched Fossilized Crystal Bed | – | | |
| Enter To Riverrise City Zone | – | | Spawns |
| Envy Sin | 19 | Mob | |
| Eric | – | NPCQuest | VendorSpawns |
| Erwin "Bacon King" Braux | – | NPCQuest | VendorSpawns |
 Escape pod | – | NPC | |
| Escape pod | – | NPC | |
| Eustice Crumble | – | NPCQuest | VendorSpawns |
| Ev Closed Area Start Cultist Island | 0 | | |
| Ev Closed Area Start Damned Bay | 0 | | |
| Ev Closed Area Wave Controller Cultist Island | 0 | Mob | |
| Ev Closed Area Wave Controller Damned Bay | 0 | Mob | |
| Ev Marker For Pillar | – | | Spawns |