| Seldon Moor | – | NPCQuest | HändlerFundorte |
 Seltene Blume | – | | |
 Seltsame Pflanze | – | | Fundorte |
 Seltsame Skizze | – | | |
| Senior-Offizier | – | NPC | |
| Sensenmann | 19 | Mob | |
| Sensenmann | 19 | Mob | |
| Sensenmann | 19 | Mob | |
 Sensenmann Erhaben | 19 | Mob | |
| Sensor | – | | Fundorte |
| Sewing Kit | – | | Fundorte |
| Sexstus | – | NPCQuest | |
| Shawna Stahlherz | – | NPC | HändlerFundorte |
| Shawna Turner | – | NPC | HändlerFundorte |
 Shiny Lure | – | | Fundorte |
| Shiny Stone | – | | |
| Shipping Manifests 01 | – | | Fundorte |
| Shipping Manifests 02 | – | | Fundorte |
| Shipping Manifests 03 | – | | Fundorte |
| Shirt Exotic Attire Acquisition | – | | Fundorte |
| Shishiga-König | 4 | NPCMob | |
 Shoreline Artifact | – | | Fundorte |
 Shrine Totem Wooden Imp 01 | – | | |
 Shrine Totem Wooden Imp 02 | – | | |
 Shrine Totem Wooden Imp 03 | – | | |
 Shrine Totem Wooden Imp 04 | – | | |
 Shrine Totem Wooden Imp 05 | – | | |
 Shrine Totem Wooden Imp 06 | – | | |
 Sicherheitschef Wreckwater | – | NPCQuest | |
| Signpost Greenville Pointer A | – | NPC | |
| Signpost Greenville Pointer C | – | NPC | |
| Signpost Greenville Pointer E | – | NPC | |
| Signpost Greenville Pointer G | – | NPC | |
| Signpost Pole Greenville Pointer A | – | NPC | |
| Signpost Pole Greenville Pointer B | – | NPC | |
| Signpost Pole Greenville Pointer C1 | – | NPC | |
| Signpost Pole Greenville Pointer C2 | – | NPC | |
| Signpost Pole Greenville Pointer D1 | – | NPC | |
| Signpost Pole Greenville Pointer D2 | – | NPC | |
| Signpost Pole Greenville Pointer D3 | – | NPC | |
| Silas Dorn | – | NPCQuest | HändlerFundorte |
| Silas Dorn | – | NPCQuest | HändlerFundorte |
| Silas Whitlock | – | NPCQuest | HändlerFundorte |
| Sirena Hexenklinge | – | NPCQuest | HändlerFundorte |
 Skalberath | – | NPCQuest | Fundorte |
| Skelett | – | Chest | |
| Skelettbogenschütze | 19 | Mob | |
| Skelettheiler | 19 | Mob | |
| Skelettkrieger | 19 | Mob | |
| Skip Stones | – | NPC | Händler |